Potential answers for "Forefront of any activity"

⭐⭐⭐⭐ VANGUARD
⭐⭐⭐ FIRINGLINE
⭐⭐ VAN
⭐⭐ POINTMAN
⭐⭐ LEADINGEDGE
⭐⭐ FIRST
⭐⭐ EMERGE
⭐⭐ NETSCAPE

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Italy's capital, to Italians   $100 bill, slangily   Prefix meaning "recent"