Potential answers for "Have cumulative negative effects"

⭐⭐⭐⭐ TAKEATOLL
⭐⭐⭐ TAKESATOLL
⭐⭐ RUNNINGGAGS
⭐⭐ YTD
⭐⭐ MILITATEAGAINST
⭐⭐ SAYNO
⭐⭐ PARLAY
⭐⭐ GRAF
⭐⭐ DAMAGE
⭐ PATE

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Punctuation mark often used in pairs   "__ teach 'em!"   Ball-bearing peg