Potential answers for "In low spirits"

⭐⭐⭐⭐ SAD
⭐⭐⭐⭐ BROKENUP
⭐⭐⭐ DOWN
⭐⭐⭐ SADLY
⭐⭐⭐ SADNESS
⭐⭐⭐ GLOOM
⭐⭐⭐ MOPE
⭐⭐⭐ BLAHS
⭐⭐⭐ ROTGUT
⭐⭐⭐ SORROW

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Corporate benefit   Herb named for its medicinal properties   British P.M. before Gladstone