Potential answers for "Significant obstacle"

⭐⭐⭐⭐ HURDLE
⭐ EPOCHAL
⭐ MAINSQUEEZE
⭐ COUNTED
⭐ LIANA
⭐ BEAU
⭐ BRA
⭐ JUMBOCDS
⭐ GREATDIVIDE
⭐ LIMPBIZKIT

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Extreme elation   Monk's garment   Fulfilled, as an order