NEF

Nef

Nef is a small 27-35 kDa myristoylated protein encoded by primate lentiviruses. These include Human Immunodeficiency Viruses and Simian Immunodeficiency Virus . Nef localizes primarily to the cytoplasm but also partially to the Plasma Membrane and is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen. Nef stands for "Negative Factor" and although it is often considered dispensable for HIV-1 replication, in infected hosts the viral protein markedly elevates viral titers.

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nef

Noun

  1. An extravagant table ornament and container used in the Middle Ages and Renaissance, made in the shape of a ship.


The above text is a snippet from Wiktionary: nef
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