PROTEOGLYCAN

Proteoglycan

Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one or more covalently attached glycosaminoglycan chain. The point of attachment is a Ser residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge . The Ser residue is generally in the sequence -Ser-Gly-X-Gly-, although not every protein with this sequence has an attached glycosaminoglycan. The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in the connective tissue.

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proteoglycan

Noun

  1. Any of many glycoproteins that have heteropolysaccharide side chains


The above text is a snippet from Wiktionary: proteoglycan
and as such is available under the Creative Commons Attribution/Share-Alike License.

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