Potential answers for "Embark on a quest, say"

⭐⭐⭐⭐ SETOFF
⭐⭐⭐ HEADWEST
⭐⭐ SETOUT
⭐⭐ SETSAIL
⭐⭐ SHOVE
⭐⭐ START
⭐⭐ BEGIN

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Initials indicating urgency   Wiped out in a big way   "Pronto!" during an operation